We found that LGR5 and stem cell-related genes were co-expressed in a subpopulation of AM epithelial cells both in vivo and in vitro, which were enriched under 3D-spheroid culture. Herein, we explored whether LGR5 + epithelial cells in AM possess stem-like cell properties and their potential contribution to pathogenesis and recurrence of AM. We have recently reported that AM harbors a subpopulation of tumor epithelial stem-like cells (AM-EpiSCs). Currently, underlying pathophysiology remains elusive, and radical surgery remains the most definitive treatment with severe morbidities. ![]() Ameloblastoma (AM) is a benign but locally aggressive tumor with high recurrences.
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